EBO2 (EBOO) therapy: frequently asked questions
Short answers to the questions people ask most about EBO2 (also called EBOO). Each answer links to a longer guide where the sources live.
The basics
Is EBO2 the same as EBOO?
Yes. EBO2 and EBOO are two names for the same procedure, extracorporeal blood oxygenation and ozonation. Some device makers and clinics brand it "EBO2"; the research literature and most clinics use "EBOO". This site uses EBO2 as the primary term and treats both as identical.
What does EBOO stand for?
EBOO stands for extracorporeal blood oxygenation and ozonation, the same procedure marketed as EBO2. Blood leaves the body through one IV line, passes through a filter and gas exchanger, picks up an oxygen and ozone mixture, and returns through a second line.
How is EBO2 different from ozone injections?
Ozone injections deliver a small amount of gas directly into a joint, disc, or muscle with a needle. EBO2 never injects gas into the body; it circulates blood outside the body, exposes it to ozone in a closed device, and returns the treated blood through an IV line.
Where is EBO2 offered?
In the United States, EBO2 is offered mainly by functional medicine and longevity practices, along with wellness clinics, that provide it as an elective, self-pay service. See our clinics page to find a listed provider.
The procedure
How long does an EBO2 session take?
Most clinics describe a session lasting 60 to 90 minutes, including IV placement in both arms, 45 to 75 minutes of blood circulation through the filter and ozone exchanger, and a short observation period afterward. See our guide on what to expect for the full walkthrough.
Does EBO2 hurt?
Most of the discomfort comes from the two IV needle placements, similar to a blood draw. Clinics report that the ozone exchange itself is not painful once the lines are in, though some people notice a metallic taste or mild lightheadedness during the session. Our guide on what to expect covers this in more detail.
How much blood is processed?
Clinics describe circulating a large fraction of the body's total blood volume during a session, continuously cycling blood through the filter and gas exchanger for roughly an hour rather than treating one fixed batch, unlike major autohemotherapy. See our what-to-expect guide for more on how a session runs.
What is in the filter afterward?
The hollow-fiber filter used during a session traps some fats, cellular debris, and inflammatory proteins as blood passes through, according to manufacturers and clinics. What it removes has not been measured in controlled studies, and the filter is discarded as single-use medical waste after each session. See our guide on what the filter actually removes for more detail.
Can I eat before a session?
Clinics generally ask patients to eat a light meal beforehand and stay hydrated, similar to guidance before a blood draw or infusion appointment. Ask your clinic for its specific pre-session instructions, since practices vary. Our guide on what to expect has general preparation tips.
How soon can I exercise after?
Most clinics say light activity is fine right away and ask patients to avoid strenuous exercise for the rest of the day, mainly to protect the IV sites from bruising and let any lightheadedness pass. Confirm timing with your own clinic, and see our guide on what to expect for more on recovery.
Cost and payment
How much does EBO2 cost?
Published US clinic prices in 2026 range from about $799 to $2,000 per session among the clinics we checked, with most listing $1,050 to $1,500. Multi-session packages are common and reduce the per-session price. Insurance does not cover it. See our cost guide for current examples with sources.
What is the cheapest way to get EBO2?
Buying a multi-session package is usually the lowest per-session price clinics publish, often 10 to 20 percent below a single visit, though the upfront total is higher. Comparing published prices across a few clinics before booking also helps, since single-session prices vary widely. See our cost guide for current examples.
Do clinics offer refunds on packages?
Rarely. Clinics that sell multi-session packages generally describe them as non-refundable once purchased, so most sources recommend booking a single session first before committing to a package. See our cost guide for how package pricing compares.
Can I use an HSA?
Sometimes. Health savings and flexible spending accounts can cover elective services in some cases, but eligibility for EBO2 specifically depends on the plan administrator, not the clinic. Confirm with your HSA or FSA provider before paying, since insurance itself does not cover EBO2. See our insurance coverage guide for more.
Safety and regulation
Is EBO2 FDA approved?
No. Ozone is not FDA-approved as a treatment for any medical condition, and no EBO2 or EBOO device is FDA-cleared for treating disease in the United States. FDA regulation 21 CFR 801.415 describes ozone as a toxic gas with no known useful medical application. Clinics offer it as an elective, out-of-pocket service. See our FDA approval guide for what this means in practice.
What are the side effects?
Clinics and case reports describe bruising or soreness at the IV site, lightheadedness, and a metallic taste as the most commonly reported effects. Rare but more serious events, including abnormal heart rhythm linked to electrolyte shifts, have been reported with ozone autohemotherapy generally. No controlled study has systematically tracked EBO2 side-effect rates. See our side effects and safety guide for the full list.
Who should not get EBO2?
Ozone is itself an oxidative stimulus, so people with G6PD deficiency, an inherited enzyme condition that leaves red blood cells vulnerable to oxidative damage, are considered poor candidates. No published checklist of EBO2 contraindications exists beyond that mechanism; anyone with a bleeding disorder or a pregnancy should raise it with a physician before booking rather than relying on a clinic's own screening alone. See our contraindications guide for more.
Can EBO2 cause a blood clot or embolism?
EBO2 circulates blood through a closed tubing circuit rather than injecting gas directly into a vein, and clinics add an anticoagulant such as heparin to the circuit to prevent clotting in the filter and lines. No published data measure clot or embolism rates specifically for EBO2. See our side effects and safety guide for more.
Is EBO2 safe with medications?
Anticoagulants and blood pressure medications are commonly relevant, since the procedure itself uses an anticoagulant and can affect circulation. Bring a full medication list to your consultation so the clinic can screen for interactions; no systematic drug-interaction data for EBO2 exist in the published literature. See our contraindications guide for more on medication interactions.
Is it safe during pregnancy?
No controlled evidence addresses EBO2 during pregnancy. Because ozone is an oxidative stimulus with unknown effects on a pregnancy, anyone who is pregnant or trying to become pregnant should discuss the decision with a physician rather than relying on a clinic's judgment alone. See our contraindications guide for more.
Conditions and evidence
Does EBO2 help Lyme disease?
No controlled trial of EBO2 for Lyme disease exists. Some clinics market ozone therapy for tick-borne illness on the theory that oxidative stress harms pathogens, but this rationale has not been tested against Lyme disease in humans in published research. See our Lyme disease guide for more.
Does EBO2 help long COVID?
No controlled trial of EBO2 for long COVID has been published. One small pilot randomized trial tested major autohemotherapy, a different ozone method that mixes a drawn batch of blood with ozone gas rather than running it through EBO2's continuous filtration circuit, in patients with post-acute COVID-19 symptoms. The trial reported greater symptom improvement in the treated group than with conventional treatment alone, but its own authors describe it as a pilot needing validation, and it did not test EBO2. Clinics that offer EBO2 for post-viral symptoms rely on general claims about oxidative signaling and circulation rather than condition-specific evidence. See our long COVID guide for more.
Does EBO2 help autoimmune disease?
No controlled trial of EBO2 for any autoimmune condition exists. A controlled, single-blind crossover trial of ozonated autohemotherapy, a related but different technique, found no significant change in two inflammatory blood markers, CRP and interleukin-6, across nine sessions in 12 hemodialysis patients, a small sample that argues against assuming ozone therapy broadly calms immune activity. See our autoimmune conditions guide for more.
Does EBO2 detox the body?
Clinics describe the filter as removing some fats, cellular debris, and inflammatory proteins as blood passes through. One published case report measured lower urinary toxin markers after treatment in a single patient, though not every marker declined. No controlled study has tested whether EBO2 changes toxin levels or health outcomes across a wider population. See our mold toxicity guide for more on these claims.
Is there any condition EBO2 is proven for?
No. EBO2 is not FDA-approved for any condition, and no large controlled trial has established that it works for a specific disease. Published research consists mainly of small studies, case reports, and reviews from the technique's own developers, a different and weaker form of evidence than an established treatment rests on. See our guides on Lyme disease, long COVID, and autoimmune disease for the evidence behind each claim.
Finding a clinic
How does EBO2.com verify clinics?
We confirm that EBO2 or EBOO is listed as a service on the clinic's own website, which becomes the recorded verification source, and require that treatment be delivered by or under a licensed clinician in that state. A listing must be re-checked if it goes more than 180 days without review; our build process rejects any listing older than that.
Does EBO2.com sell Featured or sponsored placements?
No. Every listing is free, and no clinic can pay for position, a badge, or a mention in an article. Directory pages show verified clinics first and then sort alphabetically. A listing shows "Verified" only once we confirm EBO2 on the clinic's own website, and a listing that has not been confirmed says so plainly instead.
How do I report a clinic making false claims?
Use the contact page and describe what you saw and where, including the clinic name and a link or screenshot if possible. Every listing agrees not to claim that EBO2 eliminates, treats, or prevents any disease, and reports are checked against that requirement.
Can my clinic be listed?
Yes, if EBO2 or EBOO appears as a service on the clinic's own website, which becomes the verification source, and treatment is delivered by or under a licensed clinician in your state. Use the For clinics page to submit a new listing or claim an existing one. Listings are free.