How to Choose an EBO2 (EBOO) Clinic: Checks You Can Run Before You Book

EBO2 (also called EBOO) draws blood from one arm, runs it through a filter and a gas-exchange device, and returns it through the other. Because it involves an extracorporeal circuit, who runs it and how carefully matters more than for most elective wellness services, and ozone therapy is not FDA-approved for any condition, so there is no FDA-approved labeling that tells a clinic how to do it. This guide is a set of checks a reader can run before booking: what clinic pages disclose, from our own dataset; how to look up a license, a board record, and a device; what to get in writing; and twelve questions to ask. To find listed clinics near you and see what each one publishes, use the clinic finder or the clinic directory.

What do clinics tell you before you book?

Often less than a reader needs. We track 8 basic facts on each clinic’s EBO2 page: a price, a package price, session length, the device, who supervises, what happens before a first session, a recommended course, and named clinicians. As of October 4, 2026, of the 174 clinics whose pages we could read, the median page stated 3 of the 8; 12 pages stated none, and the most any page stated was 7 [12]. The full breakdown is under “From our data” at the end of this page.

Three gaps matter most for vetting [12]:

• Who is in charge. 100 of the 174 pages say who supervises sessions, but 56 of those 100 use general wording, such as “performed under medical supervision” or “trained professionals,” without naming a role or a person. 48 pages neither name a clinician nor say who supervises.
• Who the named people are. 75 pages name at least one clinician, 137 people in all. Their listed credentials, with how many people list each: MD 31; DO 10; physician with no degree given 2; nurse practitioner or advanced practice nurse 24; registered or licensed practical nurse 13; naturopathic doctor 13 (ND 7, NMD 6); chiropractor 5; acupuncturist 5; massage therapist 2; dietitian 1; midwife 1; listed only as “Dr.” 2; no credential given 28. A named person is not necessarily the one who runs the circuit.
• What it costs. 40 of the 174 publish a single-session price, and 68 publish none of a price, a device, or a clinician’s name.

A page that leaves these out is not necessarily hiding them, but each gap is a question to ask before booking.

Check the license yourself

State license lookups are public. Florida’s Department of Health portal “provides direct access to the division’s online License Verification tool, which allows users to search the Division’s database by licensee name or license number,” and also lets users “search disciplinary actions” and “view practitioner profiles” [1]. California’s Department of Consumer Affairs search is a single tool to “verify a license issued by the Department of Consumer Affairs” across boards that include the Medical Board, the Osteopathic Medical Board, the Board of Registered Nursing, and naturopathic doctors [2]. For another state, search for that state’s medical, osteopathic, and nursing boards by name.

The federal NPI Registry is a second check: a free, “query-only database which is updated daily,” searchable by provider name or number [3]. The NPI itself is “a unique identification number for covered health care providers,” used in insurance transactions, and the number carries no other information about the provider [13]. It is not a license, so the state lookup comes first.

Board records also show what a board has done. In 2024 the Medical Board of California placed a physician on five years’ probation and ordered that “During probation, Respondent is prohibited from performing intravenous ozone therapy treatment” [8]. The case concerned intravenous ozone, not EBOO [8]; it shows the kind of entry a disciplinary search can turn up.

Who runs the circuit, and how were they trained?

A license confirms a credential, not experience with this procedure. Ask how long the clinic has offered EBO2, how many sessions the team has run, and whether the person operating the circuit has training in extracorporeal blood handling rather than only IV placement. Ask where that training came from: the equipment maker, another clinic, or a course. Machines differ. As of October 4, 2026, 21 of the 174 readable pages named the device or system they use [12]; training on one system does not automatically carry over to another. A clinic confident in its protocol usually answers these questions directly.

Single-use equipment and infection control

EBO2 shares the infection-control basics of any procedure that draws and returns blood through IV access. CDC’s core practices for every healthcare setting say to “Use needles and syringes for one patient only,” to “Use fluid infusion or administration sets (e.g., intravenous tubing) for one patient only,” and to “Clean and reprocess (disinfect or sterilize) reusable medical equipment … prior to use on another patient or when soiled,” following manufacturers’ instructions [4]. They also call for “one or more qualified individuals with training in infection prevention and control” to manage a facility’s program [4].

As of October 4, 2026, 14 of the 174 readable pages stated that the circuit, filter, or tubing is single-use [12]. The rest do not say either way. Ask directly whether the filter, the tubing, and every part that touches blood or ozone is discarded after each patient, and how anything reusable is reprocessed.

Screening before a first session

A careful clinic asks before the first session. As of October 4, 2026, 132 of the 174 readable pages described some step before a first session. In the intake statement we recorded for each, 83 describe a consultation, 33 mention lab tests or bloodwork, and 11 name a G6PD test [12]. What matters is whether a clinician reviews your history and medicines before the session is booked, not only whether a form exists. Our guide to contraindications covers what clinics screen for, and the questions for your doctor tool turns a reader’s situation into questions to take to their own clinician before deciding.

Monitoring and emergencies

Ask what is monitored during the session, what happens if a patient feels unwell partway through, what emergency equipment is on site, and who can be called after leaving. As of October 4, 2026, 15 of the 174 readable pages said vital signs are taken or monitored at a session, 11 of them during the treatment itself, and we found no saved page that described an emergency plan or the resuscitation equipment on hand [12]. That is not proof a clinic has none, only that the page does not say, so the question has to be asked. Our side effects guide covers what has been reported.

The protocol, in writing

A documented protocol states how much blood is processed, at what ozone concentration, for how long, and what is monitored. Published studies show what that level of detail looks like: the controlled trial from the technique’s developers randomized 28 patients with peripheral artery disease to EBOO or intravenous prostacyclin and named its primary measures: skin lesions, pain, quality of life, and blood flow in the legs [6]. A reader is not expected to judge the science in a clinic lobby, but a clinic that can state its protocol in those terms has one. Our research library records what each study used.

Claims and FDA wording

Ozone therapy is not FDA-approved, and the FDA’s rule calls ozone “a toxic gas with no known useful medical application in specific, adjunctive, or preventive therapy” [7]. A page that calls the treatment FDA-approved is wrong. Registration with the FDA is not approval, and the FDA issues no device registration certificates [9]; to check whether a named device was cleared or approved, search Devices@FDA by device or company name [10]. The FDA has acted on such equipment: in 2025 it warned an EBOO equipment maker that its devices lacked premarket approval and that it had not notified the agency before selling them [5]. Our guide to reading a clinic’s EBO2 page takes each common phrase in turn, from “FDA-cleared equipment” to “supports detox pathways,” with the regulators’ own words and a one-page checklist.

Price, packages, and terms

A clinic should be able to give the price of one session, every fee around it, and its package and refund terms before anyone pays. Our cost guide shows what clinics publish and what a published price can leave out, and the price check places a quote against every published price. Because we found no evidence that health insurance pays for EBO2, the terms are in practice between the patient and the clinic, which is why they belong in writing; our insurance guide covers HSA and FSA rules.

What our directory checks, and what it does not

A clinic is listed in our directory when public sources or the clinic itself indicate that it offers EBO2 or EBOO. “Verified” means that on the date shown we confirmed, on the clinic’s own website, that it offers EBO2 or EBOO, and the listing links to that page; the editorial policy shows how many listings are verified today [11]. That is the whole of the verification: it does not cover licensure, safety, or results, and a listing is not a recommendation. Clinics are listed free, and nothing a clinic does or pays changes where its listing appears or which badges it shows [11].

What to get in writing before the first session

1. The single-session price, every other fee, and what each covers.
2. Package terms: the total, the number of sessions, and what happens to sessions not used.
3. The names and license types of the people who will supervise and run the session.
4. The device’s maker and model, and the 510(k) number of anything the clinic says is FDA-cleared.
5. The protocol: blood volume, ozone concentration, session length, and what is monitored.
6. What screening happens first, including any required lab tests and who bills for them.
7. The plan if something goes wrong during a session, and a number to call afterward.
8. A copy of the consent form, to read before the day of the session.

Twelve questions to ask

1. Who is licensed, with which license, and who runs my session?
2. How many EBO2 sessions has this team performed?
3. Which device do you use, and where did the operator train on it?
4. Are the filter, the tubing, and every part that touches blood single-use?
5. What health history and screening do you require, and who reviews it?
6. What do you monitor during the session?
7. What is your plan if I have a reaction during the session?
8. What blood volume, ozone concentration, and session length does your protocol use?
9. Can I have your price list, package terms, and refund policy in writing?
10. Do you describe EBO2 as FDA-approved? (The correct answer is no.)
11. What do you tell patients about the evidence for EBO2?
12. Can I speak with the supervising clinician before I book?

What we could not verify

• Who actually performs sessions. Pages name clinicians, but not always the person who runs the circuit; we cannot tell from a page who is in the room.
• Licenses. We did not look up the licenses of the 137 people named on clinic pages.
• What clinics do but do not publish. Monitoring, emergency equipment, single-use parts, and screening may exist at clinics whose pages do not mention them.
• State rules. We did not survey which license types each state allows to run an extracorporeal circuit.
• Credentials as written. We recorded credentials as clinics list them and did not check them against any board.

How this guide was made

This guide rests on 14 sources: two state license portals, two federal pages on the NPI Registry and the NPI, CDC’s core infection-control practices, two medical board decisions, three FDA documents and databases, one federal regulation, one peer-reviewed trial, our editorial policy, and our own clinic dataset, which anyone can download. Every figure marked “As of October 4, 2026” was computed from that dataset: 177 directory listings, read between September 28, 2026 and October 4, 2026, of which 174 had EBO2 pages we could read with confidence. The supervision, single-use, and monitoring counts were classified by reading each saved page. Drafting used AI tools. A human editor has not yet checked this guide claim by claim against its sources, and no clinical reviewer has signed off yet.