How to Choose an EBO2 (EBOO) Clinic: 12 Questions to Ask Before You Book

EBO2 (also called EBOO) is an elective, out-of-pocket procedure that draws blood from the body, passes it through a filter and gas-exchange device, and returns it through the other arm. Because it involves an extracorporeal circuit rather than a simple injection, who performs it and how carefully matters more than for most elective wellness services. It also is not FDA-approved and sits outside the kind of routine oversight that applies to, say, a standard blood draw at a hospital lab, which shifts more of the burden onto you to ask the right questions before you book. See what EBO2 is and how the procedure works if you want that background first. This guide is a working checklist, twelve questions and what to listen for in the answers, plus a plain description of what our own clinic directory checks and what it does not.

Start with the license: who performs and who supervises

Ask by name who is licensed and who is in the room for your session. Depending on the state, the person running the circuit may be a physician, a nurse practitioner, a physician assistant, or a registered nurse working under a licensed prescriber. You can independently check whether a named practitioner holds an active license through your state’s medical board lookup, several of which are public and free to search; Florida’s, for example, lets anyone check license status, issue and expiration dates, and any disciplinary history for a named provider [1]. The National Provider Identifier registry is a second, faster check: entering a name returns the practitioner’s NPI number, taxonomy (specialty), and registered practice address, which lets you confirm that the person named on a clinic’s website is a real, currently enumerated healthcare provider [2]. Neither tool tells you whether someone is good at EBO2 specifically, but both take under a minute and rule out an unlicensed operation.

Training and experience with extracorporeal circuits

Licensing confirms a credential, not experience with this specific procedure. Ask how long the clinic has offered EBO2, how many sessions the team has run, and whether the person operating the circuit has training specific to extracorporeal blood handling rather than only general phlebotomy or IV placement. Ask, too, whether that training came from the equipment manufacturer, a peer clinic, or a course, since EBO2 machines vary in how they are set up and monitored, and training on one system does not automatically transfer to another. A clinic confident in its protocol will usually answer this directly, often naming the device it uses and where its staff trained on it; a vague answer, or a refusal to say who is actually trained, is itself useful information.

Single-use consumables and infection control

EBO2 shares a basic infection-control profile with any procedure that draws and returns blood through IV access: needles, tubing, and filtration cartridges should be used for one patient only. Federal guidance for outpatient settings is explicit on this point, instructing clinics to “use needles and syringes for one patient only,” to dedicate single-dose vials and IV administration sets to one patient, and to keep at least one person with infection-control training available to the facility [3]. That same guidance requires any genuinely reusable equipment to be cleaned and disinfected or sterilized before it touches another patient, following the manufacturer’s instructions rather than an in-house shortcut [3]. Ask directly whether the filter, tubing, and any insufflation or ozone-contact components are single-use, and whether the clinic can describe its reprocessing procedure for anything that is reusable. A clinic that cannot answer this plainly is asking you to trust a step that federal outpatient guidance treats as basic, not optional [3].

Screening: labs, contraindication questions

A responsible clinic asks before it treats: current medications, relevant health history, and whatever conditions its own protocol excludes. What a clinic screens for varies, so the useful question is simply whether screening happens at all, whether it is done by a clinician rather than a front-desk intake form, and whether it happens before you are already on the table. Ask specifically whether a clinician reviews your intake form and has a chance to ask follow-up questions, or whether the form is simply filed. A clinic that moves straight from a phone call to a scheduled IV session, with no health-history review in between, has skipped a step that more careful clinics build in, and it is reasonable to ask why.

Emergency readiness

Ask what the clinic does if something goes wrong mid-session, whether resuscitation equipment is on site, and whether staff are trained in it. Ask, too, what happens if you feel unwell after you leave: is there a clinician on call, and what number would you actually use. This is a fair question for any clinic running IV procedures, and a clinic that has thought about it will have a specific answer rather than a general reassurance. A clinic operating out of a spa or salon-style setting, without the emergency equipment and staffing a medical office would have, is worth asking about directly rather than assuming.

Written protocol, ozone concentration, and monitoring

A well-documented EBO2 protocol specifies how much blood is processed, at what ozone concentration, for how long, and what is monitored during the session. Published clinical use of EBOO gives a sense of what that level of detail looks like: a controlled trial from the technique’s original developers randomized 28 patients with peripheral artery disease to EBOO or intravenous prostacyclin, with a defined number of treatments per patient and prespecified outcomes tracked before and after [5]. You are not expected to evaluate the science yourself in a clinic lobby, but a clinic that can describe its protocol in similarly concrete terms, volume treated, concentration, session length, what is monitored, is showing you it has one. A clinic that answers only in marketing language has not.

Honest claims: red-flag language

Two clinic websites offering the same procedure can read very differently. One EBOO provider we reviewed names its treating physicians, states its price per session and package rate, and describes the mechanism in comparatively measured terms [6]. Another describes only “trained medical professionals” without naming anyone, publishes no price, and pairs promotional language like “detoxify” and “optimize” with broad claims about supporting the body’s “natural healing systems,” without linking any of it to a specific study [7]. Neither page claims outright that EBO2 eliminates a disease, but the difference in what each disclosed, who is treating you, what it costs, what the claims rest on, is exactly the kind of gap this checklist is meant to help you notice. Treat any claim that ozone therapy is FDA-approved, or any promise that treatment outcomes are assured, as disqualifying on its own: ozone is not FDA-approved to treat any condition, and federal rules describe it as a toxic gas with no known useful medical application in specific, adjunctive, or preventive therapy [8]. Clinics do get pursued over this. In 2025, the FDA warned a device maker selling EBOO and ozone/UV blood-irradiation equipment that its products lacked the premarket clearance required to market them for treating autoimmune, cardiovascular, and respiratory disease, and that the company had not notified the agency before introducing the devices [4]. A clinic repeating claims that its equipment treats or reverses disease is repeating exactly the kind of claim that draws that scrutiny.

Pricing transparency and package terms

A clinic should be able to tell you the price of a single session and any package terms, refund policy, and expiration date on prepaid sessions, before you pay for anything. See our cost guide for sourced examples of what US clinics charge and how packages are typically structured. Ask specifically what happens if you stop after one or two sessions of a prepaid package: whether the remainder is refundable, transferable, or simply forfeited. Because EBO2 is not covered by insurance, price and payment terms are entirely between you and the clinic, which is exactly why they should be written down rather than described only verbally; our insurance and payment guide covers HSA and FSA eligibility in more detail.

Verification: how our directory checks clinics, and what it does not

Our clinic directory lists a clinic once we find EBO2 or EBOO offered on that clinic’s own website, and marks it “verified” along with the date an editor confirmed that. That is the entire verification claim: our listings verify only that EBO2 is offered, not a clinic’s licensure, safety record, or outcomes, and a listing on our site is not a recommendation. No clinic can pay for position or a badge on our directory. Verified listings come first and the rest is alphabetical. On other directories, a “Featured” or “Sponsored” label means paid placement, nothing more, and it says nothing about how a listing was verified. Our full editorial policy describes how listings and verification work in more detail.

A printable question list

1. Who is licensed, and who performs my session.
2. How many EBO2 sessions has this team run.
3. Are the filter and tubing single-use.
4. What health history or screening do you require before treatment.
5. What is your plan if I have a reaction during the session.
6. What ozone concentration and blood volume does your protocol use.
7. Can I see your price list, including package terms and refund policy.
8. Do you claim EBO2 is FDA-approved (a correct answer is no).
9. Who owns and operates this clinic.
10. Do you accept HSA or FSA payment, and have you confirmed that with a plan administrator.
11. What do you tell patients about the evidence behind EBO2.
12. Can I speak with the clinician directly before booking.

Bottom line

Choosing an EBO2 clinic is less about finding the lowest price and more about finding a clinic willing to answer direct questions about licensing, protocol, and claims. A clinic that names its clinicians, discloses its pricing, and describes its protocol in specific terms is behaving differently from one that answers only in marketing language [6][7]. Our directory can tell you that a clinic offers EBO2; it cannot tell you that a clinic is safe, well run, or worth your money, which is exactly what these twelve questions are for.