Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease
Di Paolo N, Bocci V, Salvo DP, et al. International Journal of Artificial Organs, 2005.
- Study type
- Randomized controlled trial
- People studied
- 28 people
- Population
- Patients with peripheral artery disease
- Published
- 2005, International Journal of Artificial Organs
- Identifiers
- PMID 16288443, DOI 10.1177/039139880502801012
What the authors reported
In 28 patients randomized to EBOO or intravenous prostacyclin, EBOO produced significantly greater regression of ischemic skin lesions and improved pain and well-being, with no significant difference in measured arterial circulation between groups.
What limits this result
Small sample of 28 patients from a single Italian center; the available abstract does not describe blinding of outcome assessment or the randomization method.
Research on the procedure itself. One study rarely settles a medical question; our guides weigh each paper against the rest of the evidence.
Where we cite this study
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A neutral, sourced explainer of EBO2 (also called EBOO): how the procedure works, what the research shows, typical cost, and the FDA's position.