Does EBO2 (EBOO) Work? An Honest Read of the Evidence
Does EBO2 (EBOO) work? Every published EBOO study, what ozone therapy generally shows, and why clinic testimonials are not the same as evidence.
EBO2 (EBOO) therapy, explained with sources
EBO2, also called EBOO, runs your blood outside the body through a filter and a gas exchanger, where it meets an oxygen and ozone mix, then returns it. This site explains what the research shows and does not show, what it costs, what can go wrong, and which US clinics offer it.
- Blood is drawn from a vein in the arm.
- An anticoagulant and a pump keep it flowing without clotting.
- A filter exposes the blood to an oxygen and ozone mix across a membrane.
- Blood returns to the arm through a second line.
What the evidence says so far
Not FDA-approved
No EBO2 device or protocol is approved to treat any condition. The FDA considers ozone a toxic gas with no known useful medical application. What that means
A small research base
We track 6 published studies of EBOO itself; 3 of them describe a single patient or a small series. See the EBOO studies, annotated
Real risks
Any circuit that takes blood outside the body carries risks such as bleeding, clotting, infection, and air in the line. Side effects and safety
Clinics in 43 states
178 clinics listed. Verified listings link to the page on the clinic's own website where an editor confirmed it offers EBO2.
Start with the questions people ask first
Every guide cites its sources and names the limits of each study.
EBO2 (EBOO) Therapy Cost in 2026: What US Clinics Charge
What EBO2 (EBOO) therapy costs at US clinics in 2026: sourced prices from eight clinics in five states, how packages work, and why insurance does not cover it.
EBO2 (EBOO) Side Effects and Safety: What the Evidence Shows
What clinics and the small EBOO research base report about side effects, the risks that come with any extracorporeal circuit, and what regulators have said.
Who Should Not Get EBO2 (EBOO)? Contraindications and Precautions
The contraindications, relative precautions, and screening questions clinics commonly use for EBO2 (EBOO), and the reasoning behind each one.
How to Choose an EBO2 (EBOO) Clinic: 12 Questions to Ask Before You Book
Twelve questions to ask before booking EBO2 (EBOO) therapy: licensing, protocol, infection control, red-flag claims, and how our directory verifies clinics.
How this site works
- 218 cited sources across our guides. Clinical review of each guide is planned.
- No testimonials. Our articles and clinic listings do not include them, and we say plainly what the FDA has and has not approved.
- Free listings. No clinic pays for its listing or its position.
Read our editorial policy and medical review process.