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EBO2 (EBOO) therapy, explained: how it works, what the research shows, and what clinics charge.

EBO2, also called EBOO, is a form of ozone therapy offered by some US wellness clinics. During a session, blood flows from a line in the arm through a filter, where it meets oxygen and ozone, and back through a second line.

We gather the published studies, what regulators have said, and what clinics state on their own pages, with a link to every source, so you can read it all in one place.

Start with the basics Find a clinic

What 174 clinics say on their own pages

We read the EBO2 pages of 174 of the 177 listed clinics and recorded what each states, with the exact words and the page's address; clinics whose pages we could not read are left out of these counts. The latest reading was on October 4, 2026. These are counts of statements, not findings about any clinic.

23% publish a price for one session, 40 of 174. The median is $1,500. 94% name a condition or health benefit on their EBO2 page, 163 of 174. 76% describe what happens before a first session, such as a consultation or lab work, 132 of 174.

Does EBO2 (EBOO) Work? The Evidence, Study by Study

Every study in our EBO2 (EBOO) library in one place: design, size, what was measured and found, its limits, and a check for any study a clinic cites.

Read the guide

What happens in a session

A clinic places two IV lines. A machine moves blood through a filter, where it meets a mix of oxygen and ozone across a membrane, and returns it. Clinics most often say a session takes 60 to 90 minutes.

What to expect, step by step, and how many sessions clinics recommend.

The EBO2 (EBOO) circuit Blood leaves a vein in the arm, receives an anticoagulant, is pumped through a filter where it meets an oxygen and ozone mix across a membrane, and returns to the arm through a second line. arm 1 2 3 4
  1. Blood is drawn from a vein in the arm.
  2. An anticoagulant and a pump keep it flowing without clotting.
  3. A filter exposes the blood to an oxygen and ozone mix across a membrane.
  4. Blood returns to the arm through a second line.
Figure 1. The EBO2 circuit, simplified. The arrows on the lines show which way the blood flows.

Clinics in 43 states

177 clinics listed. Verified listings link to the page on the clinic's own website where we confirmed it offers EBO2.

Questions people ask first

Every guide cites its sources and names the limits of each study.

All 28 guides

How this site works

Read our editorial policy and medical review process.