A systematic review of ozone therapy for treating chronically refractory wounds and ulcers
Wen Q, Liu D, Wang X, et al. International Wound Journal, 2022.
- Study type
- Systematic review / meta-analysis
- People studied
- Total not recorded
- Population
- People with chronic wounds and ulcers, mainly diabetic foot ulcers, pooled from 12 randomized trials
- Published
- 2022, International Wound Journal
- Identifiers
- PMID 34612569, DOI 10.1111/iwj.13687
What the authors reported
Pooling 12 randomized trials of topical or systemic ozone therapy for chronic wounds, this review found ozone accelerated wound-area improvement and reduced amputation rate for diabetic foot ulcers versus standard care, though complete wound healing rates and hospital stay did not differ, with no reported adverse events attributed to ozone across included studies.
What limits this result
Included trials varied widely in ozone delivery method and wound type; the authors state evidence for wound types other than diabetic foot ulcers remains uncertain due to insufficient studies.
Other ozone methods, such as major autohemotherapy, that clinics cite in support of EBO2. A result for one method does not transfer automatically to another. One study rarely settles a medical question; our guides weigh each paper against the rest of the evidence.
Where we cite this study
What Is EBO2 (EBOO) Therapy? Procedure, Evidence, Cost, and Safety
A neutral, sourced explainer of EBO2 (also called EBOO): how the procedure works, what the research shows, typical cost, and the FDA's position.