Hyperbaric Oxygen Treatment for Arterial Gas Embolism With Transient Cortical Blindness Following Intravenous Ozone Therapy: A Case Report
Singh S, Nevarez J. Undersea & Hyperbaric Medicine, 2026.
- Study type
- Case report
- People studied
- 1 person
- Population
- 64-year-old woman with sudden left leg weakness and loss of vision in both eyes after a session of intravenous ozone therapy
- Published
- 2026, Undersea & Hyperbaric Medicine
- Identifiers
- PMID 42365944
What the authors reported
After a session of intravenous ozone therapy, a 64-year-old woman had sudden left lower extremity weakness and bilateral vision loss. Initial imaging showed no acute abnormality, but her presentation was consistent with cerebral arterial gas embolism. After hyperbaric oxygen at 2.8 ATA and further sessions at 2.0 ATA, her visual and motor deficits resolved fully.
What limits this result
Single case report, read from the abstract only. The gas embolism was a clinical diagnosis, since initial imaging showed no acute abnormality; the abstract gives no ozone dose or volume, no method of intravenous administration, and no number of hyperbaric sessions.
Harms reported after ozone therapy, and studies of how ozone exposure affects health. One study rarely settles a medical question; our guides weigh each paper against the rest of the evidence.
How the study was done
- Design
- Case report
Hyperbaric Oxygen Treatment for Arterial Gas Embolism With Transient Cortical Blindness Following Intravenous Ozone Therapy: A Case Report
- Setting
- Department of Internal Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA (first-listed affiliation)
- Read from
- Read from the abstract only; where this page says nothing about an item, the abstract does not report it. Read on October 2, 2026.
Source: Abstract on PubMed
Study arms
| Group | Participants | What they received |
|---|---|---|
| Single patient: 64-year-old woman | Not reported | A session of intravenous ozone therapy |
Source: Abstract on PubMed
What it measured
- Symptoms after the session
- Sudden onset of left lower extremity weakness and bilateral vision loss
This case report describes a 64-year-old female patient who experienced a sudden onset of left lower extremity weakness and bilateral vision loss following a session of intravenous ozone therapy.
- Initial diagnostic imaging
- No acute abnormalities
- Clinical assessment
- Presentation consistent with cerebral arterial gas embolism (CAGE)
- Hyperbaric oxygen treatment and course
- Emergent hyperbaric oxygen at 2.8 ATA, then additional sessions at 2.0 ATA; progressive improvement and full resolution of visual and motor deficits
- Authors' conclusion
- Hyperbaric oxygen treatment should be considered an option for patients with arterial gas embolism after intravenous ozone therapy
Source: Abstract on PubMed
Safety as reported
Cerebral arterial gas embolism, diagnosed from the clinical presentation, after intravenous ozone therapy; the authors list it among the potential complications of the procedureThis case highlights the importance of recognizing the potential complications of intravenous ozone therapy, including CAGE.
Source: Abstract on PubMed
Funding and conflicts
The authors declare no conflicts of interest
Source: Abstract on PubMed
Where we cite this study
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