Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience
Rowen RJ. Medical Gas Research, 2019.
- Study type
- Review
- People studied
- No participants of its own (review)
- Published
- 2019, Medical Gas Research
- Identifiers
- PMID 31898609, DOI 10.4103/2045-9912.273962
What the authors reported
A narrative review arguing ozone therapy could serve as an adjunctive or stand-alone treatment for drug-resistant infections and outbreaks such as Ebola, describing it as having a strong safety record.
What limits this result
A single author's advocacy-oriented narrative review with no systematic search or new controlled data, and no study of ozone against Borrelia or Lyme disease specifically.
Other ozone methods, such as major autohemotherapy, that clinics cite in support of EBO2. A result for one method does not transfer automatically to another. One study rarely settles a medical question; our guides weigh each paper against the rest of the evidence.
How the study was done
- Design
- Review concentrating on ozone therapy (OT) as a treatment for infection
- Setting
- Private Medical Practice, Santa Rosa, CA, USA
- Read from
- Read from the full text of the paper. Read on September 28, 2026.
Safety as reported
The review cites Jacobs as reporting ozone therapy to be exceptionally safe, with a complication rate of only 0.7 per 100,000 treatments, virtually all due to improper application
Source: Full text on PubMed Central
Funding and conflicts
Conflicts of interest: None
Source: Full text on PubMed Central
Where we cite this study
Does EBO2 (EBOO) Work? The Evidence, Study by Study
Every study in our EBO2 (EBOO) library in one place: design, size, what was measured and found, its limits, and a check for any study a clinic cites.
EBO2 (EBOO) for Lyme Disease: Clinic Claims, the Missing Evidence, and Standard Care
Nearly half the EBO2 (EBOO) clinics we read list Lyme disease. What they claim, why no study has tested ozone against Lyme, and what CDC lists as care.
Ozone Therapy Adverse Events by Route: What Case Reports Show, and Where EBO2 (EBOO) Fits
Every ozone therapy adverse event we could read in case reports and series, grouped by route, plus how to search FDA's MAUDE data and report to MedWatch.