Safety, pitfalls, and misunderstandings about the use of ozone therapy as a regenerative medicine tool. A narrative review
Re L, Noci JB, Gadelha Serra ME, Mollica P, et al. Journal of Biological Regulators and Homeostatic Agents, 2020.
- Study type
- Review
- People studied
- No participants of its own (review)
- Population
- Published case reports of adverse reactions attributed to ozone therapy, discussed by technique of administration
- Published
- 2020, Journal of Biological Regulators and Homeostatic Agents
- Identifiers
- PMID 33176412
What the authors reported
Discussing published case reports of adverse reactions attributed to ozone therapy, by technique of administration, the authors state that most safety issues are secondary to infections or traumatic reactions due to malpractice, and that the ozone molecule itself is commonly not responsible for severe reactions under the therapeutic modalities.
What limits this result
Narrative review, read from the abstract only. The abstract states no search method, number of reports reviewed, or event counts, and gives no counted figures for its statement that the millions of patients treated worldwide over 40 years demonstrate the therapy's safety.
Harms reported after ozone therapy, and studies of how ozone exposure affects health. One study rarely settles a medical question; our guides weigh each paper against the rest of the evidence.
How the study was done
- Design
- Narrative review
Safety, pitfalls, and misunderstandings about the use of ozone therapy as a regenerative medicine tool. A narrative review
- Setting
- Facoltà di Medicina e Chirurgia, Università Politecnica delle Marche (first-listed affiliation)
- Read from
- Read from the abstract only; where this page says nothing about an item, the abstract does not report it. Read on October 2, 2026.
Source: Abstract on PubMed
What it measured
- Focus of the review
- Reported adverse reactions, discussed mainly by technique of administration rather than the contact of ozone with biological material
- Cause of most safety issues in the published case reports
- Secondary to infections or traumatic reactions due to malpractice
The case reports on OT treatments safety concerns discussed on international journals, make it possible to state that most safety issues are secondary to infections or traumatic reactions due to malpractice.
- Role of the ozone molecule
- Commonly not responsible for severe reactions at the therapeutic modalities
- Authors' conclusion on safety
- The patients treated by physicians practicing ozone therapy worldwide over the last 40 years demonstrate its safety
The millions of patients treated so far from the thousands of physicians correctly practicing OT world widely in the last 40 years demonstrate the safety of this simple and cost-effective regenerative medicine tool.
Source: Abstract on PubMed
Safety as reported
The authors attribute most safety issues in published case reports to infections or traumatic reactions due to malpractice
Source: Abstract on PubMed
Where we cite this study
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