SIOOT recommendations for the optimal application of the oxygen-ozone therapy in clinical medicine
Franzini M, Vaiano F, Tirelli U, et al. International Immunopharmacology, 2025.
- Study type
- Other
- Published
- 2025, International Immunopharmacology
- Identifiers
- PMID 39657536, DOI 10.1016/j.intimp.2024.113751
What the authors reported
A professional-society position paper arguing that oxygen-ozone therapy needs standardized protocols and physician training, stating that inconsistent practice currently limits safety, efficacy, and reproducibility across the field.
What limits this result
A recommendations and position statement from an ozone-therapy society (SIOOT), not a controlled study; reports no new patient outcomes or trial data of its own.
Other ozone methods, such as major autohemotherapy, that clinics cite in support of EBO2. A result for one method does not transfer automatically to another. One study rarely settles a medical question; our guides weigh each paper against the rest of the evidence.
How the study was done
- Design
- Recommendations document from a scientific society (SIOOT) on applying oxygen-ozone therapy
SIOOT recommendations for the optimal application of the oxygen-ozone therapy in clinical medicine.
- Setting
- Italian Scientific Society of Oxygen-Ozone Therapy (SIOOT), Bergamo, Italy; University of Pavia, Italy (first-listed affiliation)
- Read from
- Read from the abstract only; where this page says nothing about an item, the abstract does not report it. Read on September 28, 2026.
Source: Abstract on PubMed
What it measured
- Statement on adoption of oxygen-ozone therapy
- Widespread adoption is hindered by inconsistent protocols and a lack of standardized guidelines
- Statement on standardizing protocols
- Described as essential to ensure the safety, efficacy, and reproducibility of treatments
- Statement on training
- Advanced training for physicians and caregivers described as paramount
Advanced training for physicians and caregivers is paramount, equipping them with evidence-based knowledge and practical expertise to administer this therapy effectively while avoiding unverified or misleading innovative approaches.
- Statement on the role of scientific societies
- Said to play a pivotal role, providing a structured framework for research, education, and dissemination of validated practices
Scientific Societies play a pivotal role in this endeavour, providing a structured framework for research, education, and dissemination of validated practices, thereby safeguarding patient welfare and fostering the responsible evolution of the field.
Source: Abstract on PubMed
Funding and conflicts
Conflict of interest statement on PubMed: the authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported
Source: Abstract on PubMed
Where we cite this study
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