# EBO2.com

> Independent, sourced guide to EBO2 (also called EBOO, extracorporeal blood oxygenation and ozonation): how the procedure works, what the peer-reviewed research does and does not show, what US clinics charge, safety and contraindications, tools and open data built from clinics' own pages, and a directory of US clinics offering it.

Key facts:
- EBO2 and EBOO are two names for the same procedure. Blood is drawn from one arm, passed through a hollow-fiber filter and an oxygen/ozone gas exchanger, and returned through the other arm, in sessions that clinics most often describe as roughly 60 to 90 minutes.
- Ozone therapy is not FDA-approved to treat any condition. FDA regulation 21 CFR 801.415 describes ozone as a toxic gas with no known useful medical application.
- The EBOO-specific literature is small and largely from the technique's developers. No large independent randomized trial has been published. We annotate 78 studies, each with a page and a structured record of what it reports.
- Among the 174 clinics whose EBO2 page we could read (read between September 28, 2026 and October 4, 2026), 40 publish a price for one session: from $750 to $2,500, median $1,500. Insurance does not cover it.
- Of those 174 clinics, 163 name a health benefit on their EBO2 page; no EBO2 device or protocol is FDA-approved for any condition.
- We hold 33 primary-source regulatory records, each with the exact language.
- A clinic is listed when public sources or the clinic itself indicate it offers EBO2 or EBOO. "Verified" means we confirmed it on the clinic's own website on the date shown. Listings are free, and no clinic pays for placement. FDA wording and health-benefit statements on clinic pages are reported only in aggregate, never per clinic.

## Core pages
- [What Is EBO2 (EBOO)? The Procedure, the Evidence, and What Regulators Say](https://ebo2.com/what-is-ebo2/): What EBO2 (EBOO) is, step by step from the papers that introduced it, how the US clinic version differs, what regulators say, and what is still unknown.
- [At-Home Ozone Therapy vs EBO2 (EBOO): What Regulators Say About Home Ozone Devices](https://ebo2.com/guides/at-home-ozone-therapy/): What the FDA, EPA, FTC and Health Canada say about home ozone devices, the injuries on record by route, and why EBO2 (EBOO) is not a home procedure.
- [Does EBO2 (EBOO) Work? The Evidence, Study by Study](https://ebo2.com/guides/does-ebo2-work/): Every study in our EBO2 (EBOO) library in one place: design, size, what was measured and found, its limits, and a check for any study a clinic cites.
- [EBO2 (EBOO) and Cancer Claims: What Regulators and Cancer Bodies Say](https://ebo2.com/guides/eboo-cancer-claims/): Cancer claims for EBO2 (EBOO), checked: what the research library holds, what regulators and cancer organizations have said, and what to ask an oncologist.
- [EBO2 (EBOO) Around the World: What Regulators Outside the US Have Said](https://ebo2.com/guides/eboo-around-the-world/): Is EBO2 (EBOO) approved in Europe or elsewhere? What regulators in Italy, Germany, Brazil, the UK, Canada, and Australia have said, in their own words.
- [EBO2 (EBOO) Devices and FDA Status: The Filter, the Ozone Generator, and the Circuit](https://ebo2.com/guides/eboo-devices-and-fda-status/): What the FDA has said about each device in an EBO2 (EBOO) circuit, what an FDA-cleared filter covers, and what FDA records show for the names clinics use.
- [EBO2 (EBOO) for Athletes: Anti-Doping Rules, the Studies, and the Claims](https://ebo2.com/guides/ebo2-for-athletes/): For athletes weighing EBO2 (EBOO): the anti-doping wording on blood manipulation, a 2018 ozone sanction, the nearest studies, and what clinics claim.
- [EBO2 (EBOO) for Autoimmune Conditions: Clinic Claims, the MS and Sjögren's Studies, and Standard Care](https://ebo2.com/guides/ebo2-for-autoimmune-conditions/): What clinics claim about EBO2 (EBOO) for autoimmune disease, what the MS, Sjögren's and RA ozone studies measured, and what NIH describes as care.
- [EBO2 (EBOO) for Long COVID: What Clinics Claim and What Has Been Studied](https://ebo2.com/guides/ebo2-for-long-covid/): What clinics claim about EBO2 (EBOO) for long COVID, the post-COVID ozone studies and their limits, what the FTC and FDA said, and what CDC calls care.
- [EBO2 (EBOO) for Longevity: What the Aging Research Does and Does Not Show](https://ebo2.com/guides/ebo2-for-longevity/): What the hormesis and ozone-and-aging reviews in our library actually measured, what regulators say about anti-aging claims for ozone, and what clinics claim.
- [EBO2 (EBOO) for Lyme Disease: Clinic Claims, the Missing Evidence, and Standard Care](https://ebo2.com/guides/ebo2-for-lyme-disease/): Nearly half the EBO2 (EBOO) clinics we read list Lyme disease. What they claim, why no study has tested ozone against Lyme, and what CDC lists as care.
- [EBO2 (EBOO) for Mold Toxicity and CIRS: Clinic Claims, Mycotoxin Tests, and the Evidence](https://ebo2.com/guides/ebo2-for-mold-toxicity/): What clinics claim about EBO2 (EBOO) for mold illness, what CDC says about urine mycotoxin tests, and what the one EBOO case report really measured.
- [EBO2 (EBOO) Side Effects and Safety: What Studies, Case Reports, and Regulators Record](https://ebo2.com/guides/side-effects-and-safety/): What the EBOO studies record about side effects, the harms documented with other ozone procedures, the risks of the circuit, and what regulators have found.
- [EBO2 (EBOO) Therapy Cost in 2026: What US Clinics Publish and What a Quote Leaves Out](https://ebo2.com/guides/ebo2-cost/): What US clinics publish for EBO2 (EBOO): single-session and package prices from our dataset, fees a quote can leave out, and how to check package math.
- [EBO2 (EBOO) vs 10-Pass Ozone: A Side-by-Side From the Primary Sources](https://ebo2.com/guides/ebo2-vs-10-pass-ozone/): EBO2 (EBOO) and 10-pass ozone compared from the papers that describe them, with the ozone-dose claim split into what was measured and what was assumed.
- [EBO2 (EBOO) vs Dialysis: How Ozone Dialysis Compares With Hemodialysis](https://ebo2.com/guides/eboo-vs-dialysis/): EBO2 (EBOO), sold as ozone dialysis, set beside hemodialysis from primary sources: the filter, what flows past it, flow rates, FDA status, and the evidence.
- [EBO2 (EBOO) vs Plasmapheresis: What Each Procedure Does to Blood](https://ebo2.com/guides/ebo2-vs-plasmapheresis/): EBO2 (EBOO) and plasmapheresis side by side from FDA records and apheresis guidelines: what each takes out or adds, how it runs, how it is regulated.
- [EBO2 (EBOO), Blood Thinners, and Other Medicines: What the Sources Say and What to Ask](https://ebo2.com/guides/eboo-blood-thinners-and-medications/): How EBOO circuits are kept from clotting, what heparin's FDA label warns, what clinics say about blood thinners, and what no source has studied.
- [How Many EBO2 (EBOO) Sessions Do You Need? What Clinics Recommend and What Studies Used](https://ebo2.com/guides/how-many-sessions/): How many EBO2 (EBOO) sessions US clinics recommend, from our dataset of clinic pages, set against the course lengths published studies actually used.
- [How to Choose an EBO2 (EBOO) Clinic: Checks You Can Run Before You Book](https://ebo2.com/guides/how-to-choose-a-clinic/): How to vet an EBO2 (EBOO) clinic: what clinic pages disclose, from our dataset, license and device lookups to run, what to get in writing, and 12 questions.
- [How to Read a Clinic's EBO2 (EBOO) Page: What "FDA-Cleared," "Detox," and Branded Names Mean](https://ebo2.com/guides/how-to-read-a-clinic-ebo2-page/): A decoder for EBO2 (EBOO) clinic pages: what FDA-registered, FDA-cleared, detox, and branded names mean under FDA and FTC rules, and how to check each one.
- [Is EBO2 (EBOO) Covered by Insurance? What Medicare, the IRS, and Clinics Say About Paying](https://ebo2.com/guides/insurance-coverage/): Whether insurance, Medicare, or HSA and FSA money can pay for EBO2 (EBOO), from federal rules and IRS publications, with what clinics say and what to ask.
- [Is EBO2 (EBOO) FDA Approved? What the FDA Has Said and How to Check a Claim](https://ebo2.com/guides/is-ebo2-fda-approved/): No. Ozone therapy, including EBO2 (EBOO), is not FDA-approved. What the FDA has said, its 2025 warning letter to an EBOO device maker, and how to check a claim.
- [Ozone Therapy Adverse Events by Route: What Case Reports Show, and Where EBO2 (EBOO) Fits](https://ebo2.com/guides/ozone-therapy-adverse-events/): Every ozone therapy adverse event we could read in case reports and series, grouped by route, plus how to search FDA's MAUDE data and report to MedWatch.
- [The History of EBO2 (EBOO): A Dated Timeline From Siena to US Clinics](https://ebo2.com/guides/history-of-ebo2/): When and where EBO2 (EBOO) began, how it reached US clinics, and how regulators responded, as a dated timeline in which every entry cites its source.
- [What Does the EBO2 (EBOO) Filter Actually Remove?](https://ebo2.com/guides/what-the-filter-removes/): What the EBO2 (EBOO) filter removes: what papers measured, what is theory borrowed from dialysis, what clinics claim, and what a filtrate lab report must show.
- [What Else EBO2 (EBOO) Clinics Sell: HBOT, Chelation, IV Drips, Stem Cells](https://ebo2.com/guides/clinic-bundles/): Counted from 177 US EBO2 (EBOO) clinic listings: which other services they sell, what each is approved or covered for, and what to ask when they are bundled.
- [What to Expect at an EBO2 (EBOO) Session: A Timeline From Clinic Pages and the Studies](https://ebo2.com/guides/what-to-expect/): An EBO2 (EBOO) visit stage by stage, from what clinic pages and the published studies say: intake and labs, preparation, the hour on the circuit, aftercare.
- [Who Should Not Get EBO2 (EBOO)? Contraindications Compared Across Sources](https://ebo2.com/guides/contraindications/): What an ozone physiologist, an Italian consensus, a trial's exclusions, and eleven EBO2 clinics list as reasons not to treat, compared condition by condition.

## Tools
- [Price check](https://ebo2.com/tools/price-check/): place a quote from a clinic against the prices clinics publish
- [Session cost planner](https://ebo2.com/tools/session-cost/): work out what a course of sessions costs, with add-ons and package math
- [Clinic finder](https://ebo2.com/tools/clinic-finder/): find listed clinics nearest a ZIP code, with what each states
- [Questions for your doctor](https://ebo2.com/tools/doctor-questions/): a checklist of questions to bring to a physician or a clinic before booking

## Reports and data
- [What EBO2 costs](https://ebo2.com/reports/ebo2-prices/): the prices US clinics publish, with every price, its page, and its date
- [What clinics tell you before you book](https://ebo2.com/reports/clinic-transparency/): which practical facts clinics state, and how they word FDA status and health benefits (aggregate only)
- [What regulators have said](https://ebo2.com/reports/regulatory-tracker/): primary-source records on ozone therapy and EBO2 from the FDA, FTC, state boards, and foreign regulators, with the exact language
- [How the EBOO studies differ](https://ebo2.com/reports/studies-compared/): every annotated study side by side: design, participants, procedure parameters as reported, adverse events as reported
- [Download the data](https://ebo2.com/data/): the clinic facts, study cards, and regulatory records as CSV and JSON, licensed CC BY 4.0

## Reference
- [Research library](https://ebo2.com/research/): every peer-reviewed study we have found, annotated with study type, size, finding, and limitations
- [FAQ](https://ebo2.com/faq/): short sourced answers
- [Glossary](https://ebo2.com/glossary/): MAH, 10-pass, hemofilter, 510(k), oxidative stress, and other terms
- [US clinic directory](https://ebo2.com/clinics/): state and city pages with verification sources and what each clinic states

## Policies
- [Editorial policy](https://ebo2.com/editorial-policy/)
- [Medical review](https://ebo2.com/medical-review/)
- [Medical disclaimer](https://ebo2.com/disclaimer/)
- [Terms of use](https://ebo2.com/terms/)
- [Privacy policy](https://ebo2.com/privacy/)

## Full text
- [llms-full.txt](https://ebo2.com/llms-full.txt): plain-text corpus of every article, FAQ, glossary term, and research annotation